Redox Modifications and Hematological Neoplasms-an Overview

Redox Modifications and Hematological Neoplasms-an Overview

Article history Received: 05-02-2014 Revised: 06-08-2014 Accepted: 05-01-2015 Abstract: Due to our current interest in the study of the relationship between hematological malignancies and oxidative stress, in this review we addressed the recent finding regarding this issue, focusing on the clinical findings concerning the oxidative status of patients diagnosed with hematological cancers. This s...

An Overview of the Epigenetic Modifications of Gene Expression in Tumorigenesis

The five leading causes of cancer-related deaths are lung (1,760,000 deaths), colorectal (862,000 deaths), stomach (783,000 deaths), liver (782,000 deaths), and breast (627,000 deaths) cancers. Epigenetic changes can alter chromatin compaction, leading to the regulation of geneexpression without changing the primary DNA sequence.Epigenetic mechanisms are normally involved incellular processes s...

DNA Repair Deficiency Associated with Hematological Neoplasms

Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview

Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative neoplasms include polycythemia vera, essential thrombocythemia and primary myelofibrosis in a subgroup called breakpoint cluster region-Abelson ...

Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview

Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as ‘Myeloproliferative Diseases’ and reevaluated by the World Health Organization classification system in 2011, myeloproliferative neoplasms include polycythemia vera, essential thrombocythemia and primary myelofibrosis in a subgroup called breakpoint cluster region-Abelson ...